DESCRIPTION
Supports the body’s natural production of collagen by providing an important dose of skin nutrients. *
FUNCTIONS
Aging is often associated with degenerative conditions. Being a fact for all organs, it is especially visually noticeable at the skin level. Skin is made of two important layers; the epidermis facing outward and the dermis sitting right underneath. Dermis contains very specialized cells called fibroblasts. Fibroblasts are endowed with very important tasks such as the production of elastin fibers and collagen fibers. Those fibers are providing the skin with elastic and resilient properties. Collagen Formula contains the building blocks and cofactors that fibroblasts need to synthesize new collagen fibers.
The epidermis is the skin layer we can touch and see while the dermis is not accessible from the outside unless there is a skin wound. Histologically, the dermis is made up of cells—the fibroblasts—embedded in a matrix—extracellular matrix (ECM)—primarily composed of collagen fibers. Fibroblasts are highly metabolically active cells as they synthesize and secrete the macromolecules (collagen fibers, elastin fibers, hyaluronic acid, and other glycosaminoglycans) forming the skeleton of the ECM. The ECM fibrillar skeleton is filled with water. The integrity of the dermal ECM is important to provide a scaffold supporting fibroblast optimal metabolic functions and, perhaps more importantly, to support skin hydration. Normal production of ECM fibrillar material by dermal fibroblasts is a sine qua non to wound healing. Fibroblast normal metabolic function is thus essential for 1) skin mechanical properties, 2) skin hydration, and 3) skin repair process. As we age, fibroblast activity weakens. Consequently, the production of ECM material (collagen, elastin, hyaluronic acid) gradually decreases. The loss of dermal ECM structural integrity has numerous outcomes on skin health such as reduction in water reservoir capacity, loss in elasticity and resiliency as well as a negative feedback on the activity of fibroblasts themselves. Imagine the muffin drying out. To darken the scenario, aging is also associated with an upregulation of collagenases; enzymes acting like microscopic scissors that directly breakdown collagen fibers. The formulation of Collagen Formula provides the essential building blocks to support metabolic functions of fibroblasts especially in the production of collagen fibers. Ultimately, one may expect better skin tonus and more optimal skin hydration levels.
FORMULA
Five Capsules Contain:
Vitamin C ..................................................................................... 2,000 mg
L-Lysine ..................................................................................... 1,000 mg
L-Proline ..................................................................................... 200 mg
In a base of Threonine
SUGGESTED USE
Adults take 5 capsules daily with meals or as directed. For best and longest-lasting results, use Collagen Formula for at least 3 months.
SIDE EFFECTS
No adverse side effects reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCES
J Brennan LA, Morris GM, Wasson GR, et al. The effect of vitamin C or vitamin E supplementation on basal and H2O2- induced DNA damage in human lymphocytes. Br J Nutr 2000;84:195-202.
Conconi MT, Tommasini M, Muratori E, Parnigotto PP. Essential amino acids increase the growth and alkaline phosphatase activity in osteoblasts cultured in vitro. Farmaco 2001 Oct;56(10):755-61
Hamilton IM, Gilmore WS, Benzie IF, et al. Interactions between vitamins C and E in human subjects. Br J Nutr 2000;84:261-7
Kurpad AV, Raj T, El-Khoury A, Beaumier L, Kuriyan R, Srivatsa A, Borgonha S, Selvaraj A, Regan MM, Young VR. Lysine requirements of healthy adult Indian
subjects, measured by an indicator amino acid balance technique. Am J Clin Nutr 2001 May;73(5):900-7.
Otsuka M, Matsuzawa M, Ha TY, et al. Contribution of a high dose of L-ascorbic acid to carnitine synthesis in guinea pigs fed high-fat diets. J Nutr Sci Vitaminol (Tokyo) 1999;45:163-71.
Tomblin FA and Lucas KH. Lysine for the management of herpes labialis. Am J Health Syst Pharm. 2001 Feb 15;58(4):298-300, 304.
